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Porcine somatotropin (pST) added in an amount of 0.5 mg.100 g BW resulted in a significantly elevated level of respiration in the liver. An immediate increase in the degradation of energy substrates in the liver was found after 3 days of pST feeding. The activities of the phosphoenolpyruvate carboxylase, glucose-6-phosphate dehydrogenase, and pyruvate kinase in the liver were activated to the same extent. The stimulation of glycolysis was accompanied by a decrease in the concentrations of metabolites of the Krebs cycle in the liver, resulting in the increase in the content of glycerate-3-phosphate. The rate of fatty acid synthesis increased during pST feeding, which resulted in the hypertrophy of the adipose tissue. In the uterus, the activities of dehydrogenases and monoglyceride lipase increased. It is concluded that pST exerts its effect on the energy metabolism of the animal by activating the Krebs cycle and glycolysis.A comparison of the effects of two beta-blockers, amlodipine and acebutolol, on left ventricular mass in mild hypertension.
To compare the effects of amlodipine and acebutolol on left ventricular mass (LVM) in patients with mild hypertension, we administered placebo, amlodipine (5 mg/day) or acebutolol (100 mg/day) for 6 months to 17 hypertensive patients with left ventricular hypertrophy (LVH). The echocardiographic indexes of left ventricular mass (LVM) and left ventricular mass index (LVMI) were significantly decreased by both amlodipine and acebutolol after 6 months. The effects of amlodipine and acebutolol were similar. These results suggest that both amlodipine and acebutolol may reduce LVM in patients with mild hypertension.Core values in a competitive world
By Brett Popple, Founder, Four Ventures
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