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Hydroxypropyl chitosan (HPC) was used as a novel vehicle for incorporation of selected preservatives into transdermal films to reduce the skin permeation rate and to provide a long-lasting-effect of the delivery system. The barrier properties of each formulation were investigated using a porcine ear skin ex vivo diffusion cell. Micrometer-sized solid lipid nanoparticles (SLNs) were prepared by a high pressure homogenization method using Compritol 888 ATO, Precirol ATO 5 and Precirol ATO 5 mixed with 20% (w/v) glycerol. The SLNs were added to a 1% HPC aqueous solution. Film casting of HPC, SLNs, and the HPC + SLN blends was performed. The HPC + SLN film was the most effective agent in inhibiting the penetration of permeants through skin. The film containing 0.25% (w/v) HPC showed the lowest penetration rate. The HPC + SLN films showed a good balance between the retention and the penetration of the permeants. The film containing 0.25% (w/v) HPC + 0.015% (w/v) SLNs showed a good retention rate and a penetration rate of less than 1% in 24h for each permeant. In vitro skin irritation tests showed no irritation on the skin treated with the HPC + SLN film.WELCOME TO LUXURY HOME CARE!
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